SIS3 | Tocris Bioscience 5291/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SIS3

catalog :

5291/10

quantity :

10 mg (also 50 mg)

price :

350 USD

more info or order :

Tocris Bioscience product webpage

citations: 8

Reference
Smith S, Chu D, Qu T, Aggleton J, Schneider R. Species-specific sensitivity to TGFβ signaling and changes to the Mmp13 promoter underlie avian jaw development and evolution. elife. 2022;11: pubmed publisher
Trevi xf1 o Villarreal J, Reynolds J, Langston P, Thompson A, Mitchell J, Franco R. Down-Regulation of a Profibrotic Transforming Growth Factor-β1/Cellular Communication Network Factor 2/Matrix Metalloprotease 9 Axis by Triamcinolone Improves Idiopathic Subglottic Stenosis. Am J Pathol. 2021;191:1412-1430 pubmed publisher
Vanden Oever M, Muldoon D, Mathews W, Tolar J. Fludarabine modulates expression of type VII collagen during haematopoietic stem cell transplantation for recessive dystrophic epidermolysis bullosa. Br J Dermatol. 2021;185:380-390 pubmed publisher
Kim J, Kang W, Kang S, Park S, Kim J, Yang S, et al. Proline-rich tyrosine kinase 2 mediates transforming growth factor-beta-induced hepatic stellate cell activation and liver fibrosis. Sci Rep. 2020;10:21018 pubmed publisher
Noskovičová N, Heinzelmann K, Burgstaller G, Behr J, Eickelberg O. Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol. 2018;314:L695-L707 pubmed publisher
Lin S, Sun L, Lyu X, Ai X, Du D, Su N, et al. Lactate-activated macrophages induced aerobic glycolysis and epithelial-mesenchymal transition in breast cancer by regulation of CCL5-CCR5 axis: a positive metabolic feedback loop. Oncotarget. 2017;8:110426-110443 pubmed publisher
Mou H, Vinarsky V, Tata P, Brazauskas K, Choi S, Crooke A, et al. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell. 2016;19:217-231 pubmed publisher
Echeverria C, Montorfano I, Sarmiento D, Becerra A, Nuñez Villena F, Figueroa X, et al. Lipopolysaccharide induces a fibrotic-like phenotype in endothelial cells. J Cell Mol Med. 2013;17:800-14 pubmed publisher

image

image 1 :

Cat.No. 5291 - SIS3 C28H27N3O3.HCl CAS No. 521984-48-5

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5291

SKU :

5291/10

product name :

SIS3

description :

Selective Smad3 inhibitor; inhibits TGF- R1 signaling

target :

Additional Transcription Factor Compounds

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

97%

storage :

Store at -20°C

observed molecular weight :

489.99

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SIS3 is a selective Smad3 inhibitor; attenuates TGF- 1-dependent Smad3 phosphorylation and DNA binding. Has no effect on Smad2, p38 MAPK, ERK or PI 3-kinase signaling. Inhibits TGF- 1-induced myofibroblast differentiation of dermal fibroblasts. Also inhibits TGF- 2-induced endothelial cell differentiation in iPSCs.

product keywords :

selective smad3 inhibitors inhibits TGF-beta1 TGF-B1 TGF- 1 receptors TGF-beta2 TGF-B2 TGF- 2 TGF-betaR1 TGF-BR1 TGF- R1 phosphorylation stem cells differentiation ipscs induced pluripotent Other Transcription Factors TGF-beta Receptors Other Differentiation Products 5291,

extended description :

Selective Smad3 inhibitor; inhibits TGF- R1 signaling

chemical name text :

1,2,3,4-Tetrahydro-6,7-dimethoxy-2-[(2E)-3-(1-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-oxo-2-propenyl]-isoquinoline hydrochloride

formula :

C28H27N3O3.HCl

formula text :

C28H27N3O3.HCl

cas num :

521984-48-5

USD :

335

USD 2025 :

350 USD

product details :

Selective Smad3 inhibitor; inhibits TGF- R1 signaling

more info or order :

Tocris Bioscience product webpage