R 268712 | Tocris Bioscience 5288 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

R 268712

catalog :

5288

quantity :

10 mg (also 50 mg)

price :

270 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5288

SKU :

5288/10

product name :

R 268712

description :

Potent and selective inhibitor of TGF- RI

target :

TGF-beta Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

363.39

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective inhibitor of the TGF- type I receptor/ALK5 (IC50 = 2.5 nM). Exhibits ~5000-fold selectivity over p38 MAPK. Suppresses development of renal fibrosis in a unilateral ureteral obstruction model. Also reduces proteinuria, glomerulosclerosis and improves renal function in an anti-Thy1 glomerulonephritis model. Orally bioavailable.

catalog number base :

5288

product keywords :

R268712 potent selective inhibitors inhibits TGF- RI TGF- TGF-betaRI TGFbRI TGFbR1 tgf-b1 ALK5 ALK receptors activin receptor-like Kinases transforming growth factor kidney TGF-beta Receptors 5288,

extended description :

Potent and selective inhibitor of TGF- RI

chemical name text :

4-[2-Fluoro-5-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]phenyl]-1H-pyrazole-1-ethanol

formula :

C 20 H 18 FN 5 O

formula text :

C20H18FN5O

cas num :

879487-87-3

2020 USD :

259

2021 USD :

270 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage