trans-ISRIB | Tocris Bioscience 5284 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

trans-ISRIB

catalog :

5284

quantity :

10 mg (also 50 mg)

price :

152 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Krokowski D, Guan B, Wu J, Zheng Y, Pattabiraman P, Jobava R, et al. GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells. Cell Rep. 2017;21:2895-2910 pubmed publisher

product information

brand :

Tocris

master code :

5284

SKU :

5284/10

product name :

trans-ISRIB

description :

Integrated stress response (ISR) inhibitor

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

451.34

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Integrated stress response (ISR) inhibitor; reverses the effects of eIF2 phosphorylation (IC50 = 5 nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2 kinases and elF2B. Blocks ATF4 production without altering the IRE1 or ATF6 responses in vitro . Displays memory enhancement in hippocampus-dependent spatial and fear-associated learning in rodents. Also promotes survivial of stem cells when used as part of small molecule cocktail. Brain penetrant.

catalog number base :

5284

product keywords :

Potent inhibitors inhibits of PERK signaling UPR unfolded protein response endoplasmic reticulum ER stress memory consolidation eIF2 alpha kinases ISR integrated stress response ISRIB stem cell maintenance self renewal DNA, RNA and Protein Synthesis Miscellaneous Compounds PERK Other ER stress/UPR Stem Cell Proliferation 5284,

extended description :

Integrated stress response (ISR) inhibitor

chemical name text :

N,N -trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]

formula :

C 22 H 24 Cl 2 N 2 O 4

formula text :

C22H24Cl2N2O4

cas num :

1597403-47-8

2020 USD :

146

2021 USD :

152 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage