trans-ISRIB | Tocris Bioscience 5284/50 product information

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product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

trans-ISRIB

catalog :

5284/50

quantity :

50 mg

price :

666 USD

citations: 2

Reference
Chen Y, Tristan C, Chen L, Jovanovic V, Malley C, Chu P, et al. A versatile polypharmacology platform promotes cytoprotection and viability of human pluripotent and differentiated cells. Nat Methods. 2021;18:528-541 pubmed publisher
Krokowski D, Guan B, Wu J, Zheng Y, Pattabiraman P, Jobava R, et al. GADD34 Function in Protein Trafficking Promotes Adaptation to Hyperosmotic Stress in Human Corneal Cells. Cell Rep. 2017;21:2895-2910 pubmed publisher

product information

brand :

Tocris

master code :

5284

SKU :

5284/50

product name :

trans-ISRIB

description :

Integrated stress response (ISR) inhibitor

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

99%

observed molecular weight :

451.34

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

trans-ISRIB is an integrated stress response (ISR) inhibitor; reverses the effects of eIF2 phosphorylation (IC50 = 5 nM) and restores cell translation capacity. Acts downstream of PERK, targeting interactions between eIF2 kinases and elF2B. Blocks ATF4 production without altering the IRE1 or ATF6 responses in vitro . Displays memory enhancement in hippocampus-dependent spatial and fear-associated learning in rodents. trans-ISRIB promotes survival of pluripotent stem cells in culture when used in combination with Chroman-1 (Cat. No. 7163), emricasan, and polyamines, a combination known as CEPT. When used as part of the CEPT cocktail, trans-ISRIB improves survival of differentiated cells following cryopreservation. Brain penetrant.

catalog number base :

5284

extended description :

Integrated stress response (ISR) inhibitor

chemical name text :

N,N -trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]

formula :

C 22 H 24 Cl 2 N 2 O 4

formula text :

C22H24Cl2N2O4

cas num :

1597403-47-8

USD 2021 :

640

USD 2022 :

666 USD

product details :

Integrated stress response (ISR) inhibitor

storage :

Store at +4°C