SCH 51344 | Tocris Bioscience 5280 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SCH 51344

catalog :

5280

quantity :

10 mg (also 50 mg)

price :

194 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Huber K, Salah E, Radic B, Gridling M, Elkins J, Stukalov A, et al. Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature. 2014;508:222-7 pubmed publisher

product information

brand :

Tocris

master code :

5280

SKU :

5280/10

product name :

SCH 51344

description :

Potent MTH1 inhibitor

target :

MTH1 Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

316.35

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent MTH1 inhibitor (Kd = 49 nM). Inhibits Ras-induced malignant transformation and increases -actin promoter-driven CAT activity in Ras-transformed cells. Has no effect on Ras-induced ERK and JNK activation. Inhibits Ras-induced membrane ruffling in REF-52 fibroblasts and blocks anchorage-independent growth of Ras-transformed tumor cell lines. Also induces DNA damage in SW480 colon cancer cells.

catalog number base :

5280

product keywords :

SCH51344 potent MTH1 inhibitors inhibits ras transformation anticancer hydrolases g proteins mutT homologue NUDT1 MutT homolog-1 (MTH1) 5280, MTH 1

extended description :

Potent MTH1 inhibitor

chemical name text :

2-[2-[(6-Methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol

formula :

C 16 H 20 N 4 O 3

formula text :

C16H20N4O3

cas num :

171927-40-5

2020 USD :

194

2021 USD :

194 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage