CCG 203971 | Tocris Bioscience 5277/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CCG 203971

catalog :

5277/10

quantity :

10 mg

price :

126 USD

citations: 3

Reference
Lionarons D, Hancock D, Rana S, East P, Moore C, Murillo M, et al. RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance. Cancer Cell. 2019;: pubmed publisher
Osmanagic Myers S, Kiss A, Manakanatas C, Hamza O, Sedlmayer F, Szabo P, et al. Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse. J Clin Invest. 2019;129:531-545 pubmed publisher
Zhu B, Rippe C, Thi Hien T, Zeng J, Albinsson S, Stenkula K, et al. Similar regulatory mechanisms of caveolins and cavins by myocardin family coactivators in arterial and bladder smooth muscle. PLoS ONE. 2017;12:e0176759 pubmed publisher

product information

brand :

Tocris

master code :

5277

SKU :

5277/10

product name :

CCG 203971

unit size :

10 mg

description :

Potent PORCN inhibitor; active in vivo

target :

Additional Transcription Factor Compounds

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

408.88

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CCG 203971 is an antifibrotic agent; inhibits fibrosis by targeting the MRTF/SRF gene transcription pathway. Selectively inhibits proliferation of SSc-derived dermal fibroblasts but not that of normal fibroblasts. Inhibits expression of CTGF, -SMA, and COL1A2 in SSc fibroblasts as well as in LPA and in TGF -stimulated fibroblasts. Prevents bleomycin-induced skin thickening and collagen deposition in vivo . Also suppresses PC-3 cell migration in scratch wound assays (IC50 = 4.2 M).

extended description :

Inhibits the MRTF/SRF gene transcription pathway; antifibrotic agent

chemical name text :

N-(4-Chlorophenyl)-1-[3-(2-furanyl)benzoyl]-3-piperidinecarboxamide

formula :

C 23 H 21 ClN 2 O 3

formula text :

C23H21ClN2O3

cas num :

1443437-74-8

USD :

121

Jul-22 :

126 USD

product details :

Inhibits the MRTF/SRF gene transcription pathway; antifibrotic agent

sizes available :

10 mg (also 50 mg)