MK 0677 | Tocris Bioscience 5272/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MK 0677

catalog :

5272/10

quantity :

10 mg (also 50 mg)

price :

220 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Pierre A, Van Schuerbeek A, Allaoui W, Van Laere S, Singewald N, Van Eeckhaut A, et al. Effects of ghrelin receptor activation on forebrain dopamine release, conditioned fear and fear extinction in C57BL/6J mice. J Neurochem. 2020;154:389-403 pubmed publisher
Tian J, Wang T, Wang Q, Guo L, Du H. MK0677, a Ghrelin Mimetic, Improves Neurogenesis but Fails to Prevent Hippocampal Lesions in a Mouse Model of Alzheimer's Disease Pathology. J Alzheimers Dis. 2019;72:467-478 pubmed publisher
Ramirez V, van Oeffelen W, Torres Fuentes C, Chruscicka B, Druelle C, Golubeva A, et al. Differential functional selectivity and downstream signaling bias of ghrelin receptor antagonists and inverse agonists. FASEB J. 2019;33:518-531 pubmed publisher
Torres Fuentes C, Pastor Cavada E, Cano R, Kandil D, Shanahan R, Juan R, et al. Quinolones Modulate Ghrelin Receptor Signaling: Potential for a Novel Small Molecule Scaffold in the Treatment of Cachexia. Int J Mol Sci. 2018;19: pubmed publisher
Pastor Cavada E, Pardo L, Kandil D, Torres Fuentes C, Clarke S, Shaban H, et al. A Novel Non-Peptidic Agonist of the Ghrelin Receptor with Orexigenic Activity In vivo. Sci Rep. 2016;6:36456 pubmed publisher

image

image 1 :

Cat.No. 5272 - MK 0677 C27H36N4O5S.CH3SO3H CAS No. 159752-10-0

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5272

SKU :

5272/10

product name :

MK 0677

description :

High affinity ghrelin receptor agonist

target :

Ghrelin Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

624.77

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MK 0677 is a high affinity ghrelin receptor agonist (pKi = 8.14). Growth hormone (GH) secretagog; stimulates GH release from rat pituitary cells in vitro (EC50 = 1.3 nM) and enhances GH plasma levels in vivo . Also attenuates isoproterenol -induced lipolysis in rat adipocytes in vitro . Orally bioavailable.

product keywords :

MK0677 high affinity ghrelin receptors agonists growth hormone GH secretagogue orally bioavailable L-163,191 Ibutamoren mesylate L-163,191 Ghrelin Receptors 5272,

extended description :

High affinity ghrelin receptor agonist

chemical name text :

2-Amino-N-[(1R)-2-[1,2-dihydro-1-(methylsulfonyl)spiro[3H-indole-3,4 -piperidin]-1 -yl]-2-oxo-1-[(phenylmethoxy)methyl]ethyl]-2-methylpropanamide methanesulfonate

formula :

C27H36N4O5S.CH3SO3H

formula text :

C27H36N4O5S.CH3SO3H

cas num :

159752-10-0

USD :

213

USD 2025 :

220 USD

product details :

High affinity ghrelin receptor agonist

alt names :

Ibutamoren mesylate,L-163,191

more info or order :

Tocris Bioscience product webpage