OICR 9429 | Tocris Bioscience 5267/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

OICR 9429

catalog :

5267/10

quantity :

10 mg (also 50 mg)

price :

231 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Xu A, Liu M, Huang M, Zhang Y, Hu R, Gingold J, et al. Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation. Nat Commun. 2023;14:1694 pubmed publisher
Westphal M, Sant P, Hauser A, Jung M, Driever W. Chemical Genetics Screen Identifies Epigenetic Mechanisms Involved in Dopaminergic and Noradrenergic Neurogenesis in Zebrafish. Front Genet. 2020;11:80 pubmed publisher

image

image 1 :

Cat.No. 5267 - OICR 9429 C29H32F3N5O3 CAS No. 1801787-56-3

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5267

SKU :

5267/10

product name :

OICR 9429

description :

High affinity and selective WDR5 antagonist

target :

Additional Lysine Methyltransferase Compounds

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

555.59

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

OICR 9429 is a high affinity WDR5 antagonist (Kd = 93 nM; IC50 = 64 nM); disrupts WDR5-MLL interaction. Exhibits selectivity for WDR5 over 22 methyltransferases and a panel of kinases, GPCRs, ion channels, and transporters. Reduces viability of acute myeloid leukemia cells in vitro . Also disrupts MLL1-RbBP5 interaction. . To request the negative control for OICR 9429, please fill out the OICR 0547 request form on the SGC website.

product keywords :

OICR9429 High affinity selective WDR5 antagonists WD repeat-containing proteins 5 antagonism sgc WD40 Lysine Methyltransferases WDR5 5267,

extended description :

High affinity and selective WDR5 antagonist

chemical name text :

N-[2-(4-Methylpiperazin-1-yl)-5-[3-(morpholin-4-ylmethyl)phenyl]phenyl]-6-oxo-4-(trifluoromethyl)-1,6-dihydropyridine-3-carboxamide

formula :

C29H32F3N5O3

formula text :

C29H32F3N5O3

cas num :

1801787-56-3

USD :

256

USD 2025 :

231 USD

product details :

High affinity and selective WDR5 antagonist

more info or order :

Tocris Bioscience product webpage