Temsirolimus | Tocris Bioscience 5264/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Temsirolimus

catalog :

5264/10

quantity :

10 mg

price :

213 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Chen H, Gao S, Liu W, Wong C, Wu J, Wu J, et al. RNA N6-Methyladenosine Methyltransferase METTL3 Facilitates Colorectal Cancer by Activating the m6A-GLUT1-mTORC1 Axis and Is a Therapeutic Target. Gastroenterology. 2021;160:1284-1300.e16 pubmed publisher
Liu J, Sharma K, Zangrandi L, Chen C, Humphrey S, Chiu Y, et al. In vivo brain GPCR signaling elucidated by phosphoproteomics. Science. 2018;360: pubmed publisher
Olmez I, Brenneman B, Xiao A, Serbulea V, Benamar M, Zhang Y, et al. Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms. Clin Cancer Res. 2017;23:6958-6968 pubmed publisher

image

image 1 :

Cat.No. 5264 - Temsirolimus C56H87NO16 CAS No. 162635-04-3

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5264

SKU :

5264/10

product name :

Temsirolimus

description :

mTOR inhibitor; antitumor

target :

mTOR Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

1030.29

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Temsirolimus is a mTOR inhibitor; inhibits tumor growth in breast cancer cell lines (IC50 values are 1.6 and 4.3 nM for SKBr3 and BT474, respectively). Inhibits HIF-1 -mediated VEGF production in breast cancer cell lines (BT474 and MDA-MB-231). Directly inhibits serum and VEGF mediated endothelial cell proliferation and morphogenesis in vitro and vessel formation in vivo . Causes G1/S cell cycle arrest in multiple cancer cell lines. Antiangiogenic. Activates autophagy.

product keywords :

Breast cancer mTOR inhibitors inhibits rapamycin kinases suppresses cell tumour tumor growth VEGF Vascular endothelial growth factor CCI-779 CCI-779 mTOR Cell Cycle Inhibitors Autophagy 5264,

extended description :

mTOR inhibitor; antitumor

chemical name text :

Rapamycin 42-[3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate]

formula :

C56H87NO16

formula text :

C56H87NO16

cas num :

162635-04-3

USD :

210

USD 2025 :

213 USD

product details :

mTOR inhibitor; antitumor

alt names :

CCI-779

more info or order :

Tocris Bioscience product webpage