PF 5274857 hydrochloride | Tocris Bioscience 5262 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PF 5274857 hydrochloride

catalog :

5262

quantity :

10 mg (also 50 mg)

price :

185 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5262

SKU :

5262/10

product name :

PF 5274857 hydrochloride

description :

High affinity and selective Smoothened (Smo) receptor antagonist

target :

Smoothened Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

473.42

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM). Exhibits 1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant.

catalog number base :

5262

product keywords :

PF5274857 hydrochloride high affinity selective smoothened Smo receptor antagonist hedgehog signaling antitumor brain penetrant orally available active Smoothened Receptors Hedgehog Signaling 5262,

extended description :

High affinity and selective Smoothened (Smo) receptor antagonist

chemical name text :

1-[4-(5 -Chloro-3,5-dimethyl[2,4 -bipyridin]-2 -yl-1-piperazinyl]-3-(methylsulfonyl)-1-propanone hydrochloride

formula :

C 20 H 25 ClN 4 O 3 S.HCl

formula text :

C20H25ClN4O3S.HCl

cas num :

1613439-62-5

2020 USD :

205

2021 USD :

185 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage