Dimethylenastron | Tocris Bioscience 5261 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Dimethylenastron

catalog :

5261

quantity :

10 mg (also 50 mg)

price :

146 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5261

SKU :

5261/10

product name :

Dimethylenastron

description :

Inhibitor of mitotic motor kinesin Eg5

target :

Kinesin Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

302.39

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM). Arrests mitosis, triggers apoptosis and up-regulates Hsp-70 expression in multiple human myeloma cell lines. Also inhibits the growth of several types of cancer cell lines (EC50 values are 330, 603, 743 and 881 nM in HCT116, Htert-HME1, BxPC3, K562 and NCI-H1299 cancer cells, respectively). Suppresses the migration and invasion of PANC1 cells in vitro . Cytoprotective.

catalog number base :

5261

product keywords :

inhibitors inhibits of mitotic motor kinesin Eg5 mitosis apoptosis inducer Hsp-70 expression PI3K/Akt pathway myeloma cell migration invasion cytoprotective antimitotic antitumor Kinesin Mitosis 5261,

extended description :

Inhibitor of mitotic motor kinesin Eg5

chemical name text :

2,3,4,6,7,8-Hexahydro-4-(3-hydroxyphenyl)-7,7-dimethyl-2-thioxo-5(1H)-quinazolinone

formula :

C 16 H 18 N 2 O 2 S

formula text :

C16H18N2O2S

cas num :

863774-58-7

2020 USD :

162

2021 USD :

146 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage