WWL 113 | Tocris Bioscience 5259 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

WWL 113

catalog :

5259

quantity :

10 mg (also 50 mg)

price :

154 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Patra K, Kato Y, Mizukami Y, Widholz S, Boukhali M, Revenco I, et al. Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nat Cell Biol. 2018;20:811-822 pubmed publisher

product information

brand :

Tocris

master code :

5259

SKU :

5259/10

product name :

WWL 113

description :

Ces3 and Ces1f inhibitor

target :

Hydrolase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

466.53

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Carboxylesterase Ces3 and Ces1f inhibitor (IC50 values are ~100 nM). Also inhibits ABHD6. Exhibits minimal activity against a panel of other serine hydrolases. Promotes lipid storage in adipocytes. Reduces weight gain in diet-induced obese mice and enhances glucose tolerance in diabetic mice. Orally active.

catalog number base :

5259

product keywords :

WWL113 carboxyesterases Ces3 ces1d cesif ABHD6 hydrolases serine lipids metabolism obesity diabetes Other Hydrolases Other Lipid Metabolism 5259,

extended description :

Ces3 and Ces1f inhibitor

chemical name text :

4 -[[[Methyl[[3-(4-pyridinyl)phenyl]methyl]amino]carbonyl]oxy]-[1,1 -biphenyl]-4-carboxylic acid ethyl ester

formula :

C 29 H 26 N 2 O 4

formula text :

C29H26N2O4

cas num :

947669-86-5

2020 USD :

171

2021 USD :

154 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage