chemical

NVP ADW 742

5247

10 mg (also 50 mg)

195 USD

5247

5247/10

NVP ADW 742

ATP-competitive inhibitor of IGF1R

Insulin and Insulin-like Receptor Inhibitors

Small Molecules

10 mg (also 50 mg)

99%

453.58

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ATP-competitive inhibitor of IGF1R (IC50 in the range of 0.1-0.2 M). Also inhibits c-Kit kinase activity (IC50 in the range of 3-5 M). Exhibits a synergistic effect with Imatinib, enhancing the sensitivity of multiple small cell lung cancer cell lines to the chemotherapeutics etoposide (Cat. No. 1226) and carboplatin (Cat. No. 2626).

5247

NVPADW742 ATP competitive inhibitors inhibits of IGF1 receptors kinases c-Kit small cell lung cancer cell lines SCLC insulin-like growth factor-1 receptor Insulin and insulin-like Receptors Insulin and Insulin-like Receptors 5247,

ATP-competitive inhibitor of IGF1R

5-[3-(Phenylmethoxy)phenyl]-7-[trans-3-(1-pyrrolidinylmethyl)cyclobutyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

C 28 H 31 N 5 O

C28H31N5O

475488-23-4

243

195 USD

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