TC-E 5008 | Tocris Bioscience 5244 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TC-E 5008

catalog :

5244

quantity :

10 mg (also 50 mg)

price :

152 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5244

SKU :

5244/10

product name :

TC-E 5008

description :

Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor; phenotypically lethal

target :

Dehydrogenase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

observed molecular weight :

215.25

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor (Ki = 120-190 nM). Displays 60-fold selectivity for mIDH1 (found in ~75% of gliomas) over wild type IDH1. Also inhibits D -2-hydroxyglutaric acid in cells expressing mIDH1 (EC50 = 2.4 M). Does not display cytotoxicity towards non-cancerous human cells. Phenotypically lethal.

catalog number base :

5244

product keywords :

TC-E5008 selective mutant isocitrate dehydrogenase 1 (IDH1) inhibitors inhibits phenotypically lethal cancer gliomas D-2-hydroxyglutaric acid SYC435 SYC 435 Isocitrate dehydrogenase 1 (IDH1) 5244,

extended description :

Selective mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor; phenotypically lethal

chemical name text :

1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone

formula :

C 13 H 13 NO 2

formula text :

C13H13NO2

cas num :

50405-58-8

2020 USD :

152

2021 USD :

152 USD

alt names :

SYC 435

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage