TC-S 7009 | Tocris Bioscience 5243 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TC-S 7009

catalog :

5243

quantity :

25 mg

price :

324 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Sasagawa T, Nagamatsu T, Morita K, Mimura N, Iriyama T, Fujii T, et al. HIF-2α, but not HIF-1α, mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts. Sci Rep. 2018;8:17375 pubmed publisher
Scheuermann T, Li Q, Ma H, Key J, Zhang L, Chen R, et al. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nat Chem Biol. 2013;9:271-6 pubmed publisher

product information

brand :

Tocris

master code :

5243

SKU :

5243/25

product name :

TC-S 7009

description :

High affinity and selective HIF-2 inhibitor

target :

HIF Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

99%

observed molecular weight :

308.65

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity and selective HIF-2 inhibitor (Kd = 81 nM). Binds to the HIF-2 PAS-B domain; disrupts HIF-2 -ARNT heterodimerization. Exhibits 60-fold selectivity for HIF-2 over HIF-1 . Decreases HIF-2 DNA-binding and attenuates expression of HIF-2 target genes in vitro .

catalog number base :

5243

product keywords :

TC-S7009 high affinity inhibits inhibitors HIF2 HIF2a HIF2alpha PASB hypoxia-inducible factors OX3 0X3 Hypoxia Inducible Factors 5243, Hypoxia Inducible Factors, Hypoxia Inducible Factor

extended description :

High affinity and selective HIF-2 inhibitor

chemical name text :

N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine

formula :

C 12 H 6 ClFN 4 O 3

formula text :

C12H6ClFN4O3

cas num :

1422955-31-4

2020 USD :

311

2021 USD :

324 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage