CLP 257 | Tocris Bioscience 5242 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

CLP 257

catalog :

5242

quantity :

10 mg (also 50 mg)

price :

210 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Ferando I, Faas G, Mody I. Diminished KCC2 confounds synapse specificity of LTP during senescence. Nat Neurosci. 2016;19:1197-200 pubmed publisher

product information

brand :

Tocris

master code :

5242

SKU :

5242/10

product name :

CLP 257

description :

Selective KCC2 activator

target :

Other Ion Pump/Transporter Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

307.34

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective KCC2 K+-Cl- cotransporter activator (EC50 = 616 nM). Exhibits selectivity for KCC2 over other KCC family members, NKCC1 and GABAA receptors, as well as 55 other receptors. Enhances Cl- transport and increases KCC2 plasma membrane expression in spinal slices with reduced KCC2 function. Alleviates hypersensitivity in rats with peripheral nerve injury.

catalog number base :

5242

product keywords :

CLP257 Selective KCC2 K+-Cl- cotransporters activators neuropathic pain K+/Cl- Cotransporter 2 5242, SLC 12A5, SLC12 A5, KCC 2, Solute Carrier Family 12 (Potassium/Chloride Transporters) Member 3, Potassium-chloride cotransporter, Neuronal K-Cl cotransporter, K-Cl symporter, Electroneutral potassium-chloride cotransporter 22

extended description :

Selective KCC2 activator

chemical name text :

(5Z)-5-[(4-Fluoro-2-hydroxyphenyl)methylene]-2-(tetrahydro-1-(2H)-pyridazinyl)-4(5H)-thiazolone

formula :

C 14 H 14 FN 3 O 2 S

formula text :

C14H14FN3O2S

cas num :

1181081-71-9

2020 USD :

203

2021 USD :

210 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage