TC-S 7006 | Tocris Bioscience 5240/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TC-S 7006

catalog :

5240/10

quantity :

10 mg (also 50 mg)

price :

339 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Matzaraki V, Gresnigt M, Jaeger M, Ricaño Ponce I, Johnson M, Oosting M, et al. An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility. PLoS ONE. 2017;12:e0180824 pubmed publisher

image

image 1 :

Cat.No. 5240 - TC-S 7006 C21H14ClFN6 CAS No. 871307-18-5

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

5240

SKU :

5240/10

product name :

TC-S 7006

description :

Potent and selective Tpl2 (Cot; MAP3K8) inhibitor

target :

Other Kinase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at -20°C

observed molecular weight :

404.83

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TC-S 7006 is a potent and selective Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50 nM). Selective for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. Inhibits LPS-induced TNF- secretion from monocytes and attenuates acute myeloid leukemia (AML) cell proliferation in vitro . Also reduces cytolytic activity of human CD8+ cytotoxic T lymphocytes. Cell permeable.

product keywords :

TC-S7006 potent selective TPL2 Cot MAP3K8 inhibits inhibitors Other Kinases 5240,

extended description :

Potent and selective Tpl2 (Cot; MAP3K8) inhibitor

chemical name text :

4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile

formula :

C21H14ClFN6

formula text :

C21H14ClFN6

cas num :

871307-18-5

USD :

335

USD 2025 :

339 USD

product details :

Potent and selective Tpl2 (Cot; MAP3K8) inhibitor

more info or order :

Tocris Bioscience product webpage