product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
IWP 4
catalog :
5214/10
quantity :
10 mg (also 50 mg)
price :
279 USD
more info or order :
citations: 15
Reference
Han L, Huang D, Wu S, Liu S, Wang C, Sheng Y, et al. Lipid droplet-associated lncRNA LIPTER preserves cardiac lipid metabolism. Nat Cell Biol. 2023;25:1033-1046 pubmed publisher
Ng W, Varghese B, Ren X. Co-differentiation and Co-maturation of Human Cardio-pulmonary Progenitors and Micro-Tissues from Human Induced Pluripotent Stem Cells. Bio Protoc. 2022;12:e4488 pubmed publisher
Michas C, Karakan M, Nautiyal P, Seidman J, Seidman C, Agarwal A, et al. Engineering a living cardiac pump on a chip using high-precision fabrication. Sci Adv. 2022;8:eabm3791 pubmed publisher
González Terán B, Pittman M, Felix F, Thomas R, Richmond Buccola D, Hüttenhain R, et al. Transcription factor protein interactomes reveal genetic determinants in heart disease. Cell. 2022;185:794-814.e30 pubmed publisher
Ng W, Johnston E, Tan J, Bliley J, Feinberg A, Stolz D, et al. Recapitulating human cardio-pulmonary co-development using simultaneous multilineage differentiation of pluripotent stem cells. elife. 2022;11: pubmed publisher
Koc A, Cagavi E. Replating Protocol for Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Methods Mol Biol. 2022;2520:161-170 pubmed publisher
Arslanova A, Shafaattalab S, Ye K, Asghari P, Lin L, Kim B, et al. Using hiPSC-CMs to Examine Mechanisms of Catecholaminergic Polymorphic Ventricular Tachycardia. Curr Protoc. 2021;1:e320 pubmed publisher
Ladha F, Thakar K, Pettinato A, Legere N, Ghahremani S, Cohn R, et al. Actinin BioID reveals sarcomere crosstalk with oxidative metabolism through interactions with IGF2BP2. Cell Rep. 2021;36:109512 pubmed publisher
Chen D, Khan N, Close B, Goel R, Blum B, Tavares A, et al. SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway. J Virol. 2021;95:e0086221 pubmed publisher
Pettinato A, Yoo D, VanOudenhove J, Chen Y, Cohn R, Ladha F, et al. Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment. Cell Rep. 2021;35:109088 pubmed publisher
Leclair N, Brugiolo M, Urbanski L, Lawson S, Thakar K, Yurieva M, et al. Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis. Mol Cell. 2020;80:648-665.e9 pubmed publisher
Sewanan L, Schwan J, Kluger J, Park J, Jacoby D, Qyang Y, et al. Extracellular Matrix From Hypertrophic Myocardium Provokes Impaired Twitch Dynamics in Healthy Cardiomyocytes. JACC Basic Transl Sci. 2019;4:495-505 pubmed publisher
Moghadasi Boroujeni S, KOONTZ A, Tseropoulos G, Kerosuo L, Mehrotra P, Bajpai V, et al. Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo. Sci Rep. 2019;9:9750 pubmed publisher
Ou J, Ball J, Luan Y, Zhao T, Miyagishima K, Xu Y, et al. iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications. Cell. 2018;173:851-863.e16 pubmed publisher
Chopra A, Kutys M, Zhang K, Polacheck W, Sheng C, Luu R, et al. Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions. Dev Cell. 2018;44:87-96.e5 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
5214
SKU :
5214/10
product name :
IWP 4
description :
Potent inhibitor of Wnt/ -catenin signaling
target :
beta-Catenin Inhibitors
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Store at +4°C
observed molecular weight :
496.62
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
IWP 4 is a potent inhibitor of Wnt/ -catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.
product keywords :
IWP4 potent inhibitors inhibits Wnt beta-catenin -catenin b-catenin cardiomyocytes ESCs iPSCs stem cells embryonic pluripotent differentiation Beta-catenin Cardiomyocyte Stem Cells ESCs and iPSC Organoids 5214,
extended description :
Potent inhibitor of Wnt/ -catenin signaling
chemical name text :
N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
formula :
C23H20N4O3S3
formula text :
C23H20N4O3S3
cas num :
686772-17-8
USD :
267
USD 2025 :
279 USD
product details :
Potent inhibitor of Wnt/ -catenin signaling
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK