E 64 | Tocris Bioscience 5208 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

E 64

catalog :

5208

quantity :

10 mg (also 50 mg)

price :

173 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Lee M, Hong S, Kim N, Shin K, Kang S. Tricyclic Antidepressants Amitriptyline and Desipramine Induced Neurotoxicity Associated with Parkinson's Disease. Mol Cells. 2015;38:734-40 pubmed publisher

product information

brand :

Tocris

master code :

5208

SKU :

5208/10

product name :

E 64

description :

Potent and irreversible cysteine protease inhibitor

target :

Synthetic Cathepsin Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

357.41

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and irreversible cysteine protease inhibitor (IC50 values are 1.4, 2.5 and 4.1 nM for cathepsin K, L and S respectively. Also inhibits papain, calpain, cathepsin B and cathepsin H. Has no effect on serine proteases. Reduces HSC-3 tongue cancer cell invasion and induces oxidative stress and apoptosis in filarial parasites. Also inhibits autophagy-associated lysosomal degradation in vitro .

catalog number base :

5208

product keywords :

E64 potent irreversible natural cysteine protease inhibitors inhibits cathepsin K L S B H calpain papain Cathepsin Calpains Calcium-Sensitive Proteases 5208,

extended description :

Potent and irreversible cysteine protease inhibitor

chemical name text :

(2S,3S)-3-[[[(1S)-1-[[[4-(Aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid

formula :

C 15 H 27 N 5 O 5

formula text :

C15H27N5O5

cas num :

66701-25-5

2020 USD :

166

2021 USD :

173 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage