STF 118804 | Tocris Bioscience 5207 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

STF 118804

catalog :

5207

quantity :

25 mg

price :

350 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Fons N, Sundaram R, Breuer G, Peng S, McLean R, Kalathil A, et al. PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma. Nat Commun. 2019;10:3790 pubmed publisher

product information

brand :

Tocris

master code :

5207

SKU :

5207/25

product name :

STF 118804

description :

NAMPT inhibitor; depletes leukemia stem cells

target :

NAMPT Inhibitors

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

461.53

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NAMPT inhibitor (nicotinamide phosphoribosyltransferase, visfatin, PBEF1); inhibits NAD+ synthesis from nicotinamide. Potently inhibits the viability of multiple B-cell acute lymphoplastic leukemia (B-ALL) cell lines (IC50 10 nM); induces apoptosis in MF-411 cells. Induces regression of ALL xenografts and eliminates leukemia stems cells from bone marrow in mice.

catalog number base :

5207

product keywords :

STF118804 NAMPT inhibitors inhibits potent nicotinamide phosphoribosyltransferase visfatin PBEF1 cytotoxic Cancer Stem Cells NAMPT 5207, PBEF inhibitors, visfatin inhibitors, nicotinamide phosphoribosyltransferase

extended description :

NAMPT inhibitor; depletes leukemia stem cells

chemical name text :

4-[5-Methyl-4-[[(4-methylphenyl)sulfonyl]methyl]-2-oxazolyl]-N-(3-pyridinylmethyl)benzamide

formula :

C 25 H 23 N 3 O 4 S

formula text :

C25H23N3O4S

cas num :

894187-61-2

2020 USD :

350

2021 USD :

350 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage