Furamidine dihydrochloride | Tocris Bioscience 5202/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Furamidine dihydrochloride

catalog :

5202/5

quantity :

5 mg (also 25 mg)

price :

112 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Tang S, Sethunath V, Metaferia N, Nogueira M, Gallant D, Garner E, et al. A genome-scale CRISPR screen reveals PRMT1 as a critical regulator of androgen receptor signaling in prostate cancer. Cell Rep. 2022;38:110417 pubmed publisher
Marsden A, Riley D, Barry A, Khalil J, Guinn B, Kemp N, et al. Inhibition of Arginine Methylation Impairs Platelet Function. ACS Pharmacol Transl Sci. 2021;4:1567-1577 pubmed publisher
Samuel S, Marsden A, Deepak S, Rivero F, Greenman J, Beltran Alvarez P. Inhibiting Arginine Methylation as a Tool to Investigate Cross-Talk with Methylation and Acetylation Post-Translational Modifications in a Glioblastoma Cell Line. Proteomes. 2018;6: pubmed publisher

product information

brand :

Tocris

master code :

5202

SKU :

5202/5

rank :

0.0006

product name :

Furamidine dihydrochloride

description :

Selective PRMT1 inhibitor

target :

Protein Arginine Methyltransferase Inhibitors

category :

Small Molecules

sizes available :

5 mg (also 25 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Furamidine dihydrochloride is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 9.4 M). Exhibits selectivity over PRMT5, PRMT6 and CARM1 (IC50 values are 166, 283 and 400 M respectively). Inhibits tyrosyl-DNA phosphodiesterase 1 (TDP-1) (IC50 = 1.2 M). Inhibits cell proliferation in leukemia cell lines, suppresses neuroblastoma tumor growth, and reduces mis-splicing in in vitro and in vivo models of myotonic dystrophy type 1. Also shows dose-dependent inhibition of platelet aggregation (IC50 = 14.8 uM). Cell-permeable.

extended description :

Selective PRMT1 inhibitor

chemical name text :

4,4 -(2,5-Furandiyl)bis-benzenecarboximidamide dihydrochloride

formula :

C 18 H 16 N 4 O.2HCl

formula text :

C18H16N4O.2HCl

cas num :

55368-40-6

USD :

112 USD

product details :

Selective PRMT1 inhibitor

storage :

Store the unopened product at room temperature. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage