chemical

AZD 7762 hydrochloride

5199

10 mg (also 50 mg)

223 USD

5199

5199/10

AZD 7762 hydrochloride

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing

Checkpoint Kinase Inhibitors

Small Molecules

10 mg (also 50 mg)

98%

398.88

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Potent and selective ATP-competitive inhibitor of Chk1 and Chk2 (IC50 vales are 5 nM for both kinases); displays at least 10 fold selectivity over a panel of 164 kinases. Potentiates cytotoxicity of DNA-damaging agents. Active in vivo . Also improves efficiency of CRISPR-Cpf1-mediated genome editing in hPSC lines (2.7-fold at 1 M).

5199

AZD7762 hydrochloride Potent selective ATP competitive inhibitors inhibits Chk1 Chk2 checkpoint kinases Checkpoint Kinases Checkpoint Control Kinases CRISPR Reagents 5199,

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide hydrochloride

C 17 H 19 FN 4 O 2 S.HCl

C17H19FN4O2S.HCl

1246094-78-9

216

223 USD

Store at -20°C