5199/10 | Tocris Bioscience 5199/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

5199/10

catalog :

5199/10

quantity :

10 mg (also 50 mg)

price :

251 USD

product information

master code :

5199

SKU :

5199/10

product name :

AZD 7762 hydrochloride

unit size :

10 mg (also 50 mg)

description :

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing

target :

Checkpoint Kinase Inhibitors

category :

Small Molecules

purity :

98%

observed molecular weight :

398.88

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZD 7762 hydrochloride is a potent and selective ATP-competitive inhibitor of Chk1 and Chk2 (IC50 vales are 5 nM for both kinases); displays at least 10 fold selectivity over a panel of 164 kinases. Potentiates cytotoxicity of DNA-damaging agents. Active in vivo . Also improves efficiency of CRISPR-Cpf1-mediated genome editing in hPSC lines (2.7-fold at 1 M).

top caption :

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing

extended description :

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing

chemical name text :

3-[(Aminocarbonyl)amino]-5-(3-fluorophenyl)-N-(3S)-3-piperidinyl-2-thiophenecarboxamide hydrochloride

formula :

C17H19FN4O2S.HCl

formula text :

C17H19FN4O2S.HCl

cas num :

1246094-78-9

USD :

251 USD

product details :

Potent and selective ATP-competitive inhibitor of Chk1 and Chk2; also enhances CRISPR-Cpf1-mediated genome editing

storage :

Store at -20░C