AZ 20 | Tocris Bioscience 5198 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZ 20

catalog :

5198

quantity :

10 mg (also 50 mg)

price :

290 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Kiliç S, Lezaja A, Gatti M, Bianco E, Michelena J, Imhof R, et al. Phase separation of 53BP1 determines liquid-like behavior of DNA repair compartments. EMBO J. 2019;:e101379 pubmed publisher
Teloni F, Michelena J, Lezaja A, Kiliç S, Ambrosi C, Menon S, et al. Efficient Pre-mRNA Cleavage Prevents Replication-Stress-Associated Genome Instability. Mol Cell. 2019;73:670-683.e12 pubmed publisher
Bowry A, Piberger A, Rojas P, Saponaro M, Petermann E. BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication. Cell Rep. 2018;25:2061-2069.e4 pubmed publisher

product information

brand :

Tocris

master code :

5198

SKU :

5198/10

product name :

AZ 20

description :

Potent and selective ATR kinase inhibitor; antitumor

target :

ATM and ATR Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

412.51

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective ATR kinase inhibitor (IC50 = 5 nM). Exhibits 7.6-fold selectivity over mTOR and selectivity over a panel of 442 kinases, including ATM kinase, PI3-K isoforms, and DNA-PK. Inhibits cell growth in cell lines with high baseline levels of replication stress. Displays antitumor effects in vivo .

catalog number base :

5198

product keywords :

AZ20 potent selective ATR Kinase inhibitors inhibits ataxia telangiectasia Rad3 related antitumor antitumour replication stress ATM & ATR Kinase Checkpoint Control Kinases 5198,

extended description :

Potent and selective ATR kinase inhibitor; antitumor

chemical name text :

4-[4-[(3R)-3-Methyl-4-morpholinyl]-6-[1-(methylsulfonyl)cyclopropyl]-2-pyrimidinyl]-1H-indole

formula :

C 21 H 24 N 4 O 3 S

formula text :

C21H24N4O3S

cas num :

1233339-22-4

2020 USD :

278

2021 USD :

290 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage