PMX 205 | Tocris Bioscience 5196/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PMX 205

catalog :

5196/1

quantity :

1 mg

price :

346 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Natarajan N, Abbas Y, Bryant D, González Rosa J, Sharpe M, Uygur A, et al. Complement Receptor C5aR1 Plays an Evolutionarily Conserved Role in Successful Cardiac Regeneration. Circulation. 2018;137:2152-2165 pubmed publisher

product information

brand :

Tocris

master code :

5196

SKU :

5196/1

rank :

0.061

product name :

PMX 205

description :

Potent C5a receptor peptide antagonist

target :

Complement Signaling inhibitors

category :

Peptides

sizes available :

1 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

PMX 205 is a potent C5a receptor peptide antagonist (IC50 = 31 nM). Ameliorates experimentally-induced colon inflammation in mice. Reduces fibrillar amyloid deposits, decreases hyperphosphorylated tau levels and rescues cognitive function in a mouse model of Alzheimer s disease. Also improves hindlimb grip strength and slows disease progression in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Orally active and brain penetrant.

extended description :

Potent C5a receptor peptide antagonist

formula :

C 45 H 62 N 10 O 6

formula text :

C45H62N10O6

cas num :

514814-49-4

USD :

346 USD

product details :

Potent C5a receptor peptide antagonist

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage