PTC 209 | Tocris Bioscience 5191/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PTC 209

catalog :

5191/10

quantity :

10 mg (also 50 mg)

price :

296 USD

citations: 2

Reference
Zhang Z, Oh M, Sasaki J, Nor J. Inverse and reciprocal regulation of p53/p21 and Bmi-1 modulates vasculogenic differentiation of dental pulp stem cells. Cell Death Dis. 2021;12:644 pubmed publisher
Su W, Han H, Wang Y, Zhang B, Zhou B, Cheng Y, et al. The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression. Cancer Cell. 2019;36:139-155.e10 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5191

SKU :

5191/10

product name :

PTC 209

Description :

Bmi-1 inhibitor; antitumor

target :

Ubiquitin Ligase (E3) Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

495.19

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PTC 209 is a Bmi-1 inhibitor (IC50 ~ 0.5 M); irreversibly impairs colorectal cancer-initiating cell (CIC) growth. Reduces tumor growth in CIC xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors in vivo .

extended description :

Bmi-1 inhibitor; antitumor

chemical name text :

N-(2,6-Dibromo-4-methoxyphenyl)-4-(2-methylimidazo[1,2-a]pyrimidin-3-yl)-2-thiazolamine

formula :

C 17 H 13 Br 2 N 5 OS

formula text :

C17H13Br2N5OS

cas num :

315704-66-6

USD :

296 USD

product details :

Bmi-1 inhibitor; antitumor

storage :

Store at -20°C