FRAX 486 | Tocris Bioscience 5190/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

FRAX 486

catalog :

5190/10

quantity :

10 mg

price :

265 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Wang Y, Gratzke C, Tamalunas A, Wiemer N, Ciotkowska A, Rutz B, et al. P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate. PLoS ONE. 2016;11:e0153312 pubmed publisher

product information

brand :

Tocris

master code :

5190

SKU :

5190/10

rank :

0.071

product name :

FRAX 486

description :

Potent PAK inhibitor; brain penetrant and orally bioavailable

target :

PAK Inhibitors

category :

Small Molecules

sizes available :

10 mg

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

FRAX 486 is a potent p21-activated kinase (PAK) inhibitor (IC50 values are 14, 33, 39 and 575 nM for PAK1, PAK2, PAK3 and PAK4 respectively). Blocks and reverses the DISC1 knockdown-induced reduction in dendritic spine size in cortical neurons. Attenuates dendritic spine elimination and enhances spine generation in DISC1 knockdown mice. Ameliorates autism-like behavioral symptoms in fragile X mental retardation 1 (Fmr1) knockout mice. Brain penetrant and orally bioavailable.

extended description :

Potent PAK inhibitor; brain penetrant and orally bioavailable

chemical name text :

6-(2,4-Dichlorophenyl)-8-ethyl-2-[[3-fluoro-4-(1-piperazinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-7(8H)-one

formula :

C 25 H 23 Cl 2 FN 6 O

formula text :

C25H23Cl2FN6O

cas num :

1232030-35-1

USD :

265 USD

product details :

Potent PAK inhibitor; brain penetrant and orally bioavailable

storage :

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage