JTE 607 dihydrochloride | Tocris Bioscience 5185 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JTE 607 dihydrochloride

catalog :

5185

quantity :

10 mg (also 50 mg)

price :

265 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Futami M, Suzuki K, Kato S, Ohmae S, Tahara Y, Nojima M, et al. The novel multi-cytokine inhibitor TO-207 specifically inhibits pro-inflammatory cytokine secretion in monocytes without affecting the killing ability of CAR T cells. PLoS ONE. 2020;15:e0231896 pubmed publisher

product information

brand :

Tocris

master code :

5185

SKU :

5185/10

product name :

JTE 607 dihydrochloride

description :

Cytokine release inhibitor; anti-inflammatory

target :

Cytokine Compounds

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

597.36

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Cytokine release inhibitor. Inhibits production of IL-1 , IL-8, IL-6, IL-10 and TNF (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. Reduces proinflammatory cytokine-release and attenuates lung permeability in a rat lung injury model. Induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model.

catalog number base :

5185

product keywords :

JTE607 dihydrochloride cytokines inhibitors inhibits TNFa TNF-alpha TNF- interleukins IL-1beta IL-1b IL-1 inflammation anti-inflammatory IL-6 IL-8 IL-10 apoptosis TO-207 Cytokines 5185,

extended description :

Cytokine release inhibitor; anti-inflammatory

chemical name text :

N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride

formula :

C 25 H 31 Cl 2 N 3 O 5 .2HCl

formula text :

C25H31Cl2N3O5.2HCl

cas num :

188791-09-5

2020 USD :

254

2021 USD :

265 USD

alt names :

TO-207

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage