JTE 607 dihydrochloride | Tocris Bioscience 5185/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

JTE 607 dihydrochloride

catalog :

5185/10

quantity :

10 mg (also 50 mg)

price :

307 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Futami M, Suzuki K, Kato S, Ohmae S, Tahara Y, Nojima M, et al. The novel multi-cytokine inhibitor TO-207 specifically inhibits pro-inflammatory cytokine secretion in monocytes without affecting the killing ability of CAR T cells. PLoS ONE. 2020;15:e0231896 pubmed publisher

product information

brand :

Tocris

master code :

5185

SKU :

5185/10

rank :

0.061

product name :

JTE 607 dihydrochloride

description :

Active metabolite binds CPSF3; Pro-drug

target :

Cytokine Compounds

category :

Small Molecules

sizes available :

10 mg (also 50 mg)

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

JTE 607 dihydrochloride is a pro-drug that is cleaved by carboxylesterase 1 (CES1) to its active metabolite, which then binds to cleavage and polyadenylation specificity factor 3 (CPSF3; Kd = 370 nM at human CPSF3). Treatment of A-673 cells with JTE 607 results in inhibition of mRNA cleavage and accumulation of nuclear R-loops. JTE 607 induces apoptosis in leukemia cells in vitro and prolongs survival in a mouse leukemia model. JTE 607 inhibits cytokine release and inhibits production of IL-1 , IL-8, IL-6, IL-10 and TNF (IC50 values are 5.9, 7.3, 8.8, 9.1 and 11.0 nM, respectively) from LPS-stimulated PBMCs. In a rat model of lung injury, JTE 607 reduces proinflammatory cytokine-release and attenuates lung permeability.

extended description :

Active metabolite binds CPSF3; Pro-drug

chemical name text :

N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride

formula :

C 25 H 31 Cl 2 N 3 O 5 .2HCl

formula text :

C25H31Cl2N3O5.2HCl

cas num :

188791-09-5

USD :

307 USD

product details :

Active metabolite binds CPSF3; Pro-drug

alt names :

TO-207

storage :

Store the unopened product at room temperature. Do not use past expiration date.

more info or order :

Tocris Bioscience product webpage