MS 436 | Tocris Bioscience 5173/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MS 436

catalog :

5173/10

quantity :

10 mg (also 50 mg)

price :

229 USD

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5173

SKU :

5173/10

product name :

MS 436

Description :

Potent and selective BRD4(1) inhibitor

target :

Bromodomain Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

383.42

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MS 436 is a potent and selective BRD4 bromodomain inhibitor (Ki = 30 - 50 nM for the first bromodomain (BRD4(1)). Exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Blocks BRD4 transcriptional activity in lipopolysaccharide-induced production of both nitric oxide and IL-6 in mouse macrophages (IC50 values are 3.8 and 4.9 M, respectively). Attenuates melanoma cell proliferation in vitro .

extended description :

Potent and selective BRD4(1) inhibitor

chemical name text :

(E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide

formula :

C 18 H 17 N 5 O 3 S

formula text :

C18H17N5O3S

cas num :

1395084-25-9

USD :

229 USD

product details :

Potent and selective BRD4(1) inhibitor

storage :

Store at -20°C