ML 240 | Tocris Bioscience 5153 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

ML 240

catalog :

5153

quantity :

10 mg (also 50 mg)

price :

210 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5153

SKU :

5153/10

product name :

ML 240

description :

ATP-competitive inhibitor of p97 ATPase

target :

Other ER Stress/UPR Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

396.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

ATP-competitive inhibitor of p97 ATPase (VCP, IC50 = 110 nM). Exhibits antiproliferative activity in NCI-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of LC3-II and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (ERAD) pathway.

catalog number base :

5153

product keywords :

ML240 ATP competitive inhibitors AAA ATPases p97 VCP valosin autophagy inhibitors inhibits Autophagy Translocation, Exocytosis & Endocytosis Other ER stress/UPR p97 ATPase Translocation 5153,

extended description :

ATP-competitive inhibitor of p97 ATPase

chemical name text :

2-(2-Amino-1H-benzimidazole-1-yl)-8-methoxy-N-(phenylmethyl)-4-quinazolinamine

formula :

C 23 H 20 N 6 O

formula text :

C23H20N6O

cas num :

1346527-98-7

2020 USD :

203

2021 USD :

210 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage