Wnt-C59 | Tocris Bioscience 5148 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Wnt-C59

catalog :

5148

quantity :

10 mg (also 50 mg)

price :

284 USD

more info or order :

Tocris Bioscience product webpage

citations: 14

Reference
Liang W, Han P, Kim E, Mak J, Zhang R, Torrente A, et al. Canonical Wnt signaling promotes pacemaker cell specification of cardiac mesodermal cells derived from mouse and human embryonic stem cells. Stem Cells. 2020;38:352-368 pubmed publisher
WARD M, Gilad Y. A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees. elife. 2019;8: pubmed publisher
Rostovskaya M, Stirparo G, Smith A. Capacitation of human naïve pluripotent stem cells for multi-lineage differentiation. Development. 2019;146: pubmed publisher
Jiang Y, Zhou Y, Bao X, Chen C, Randolph L, Du J, et al. An Ultrasensitive Calcium Reporter System via CRISPR-Cas9-Mediated Genome Editing in Human Pluripotent Stem Cells. iScience. 2018;9:27-35 pubmed publisher
Pavlovic B, Blake L, Roux J, Chavarria C, Gilad Y. A Comparative Assessment of Human and Chimpanzee iPSC-derived Cardiomyocytes with Primary Heart Tissues. Sci Rep. 2018;8:15312 pubmed publisher
Montefiori L, Sobreira D, Sakabe N, Aneas I, Joslin A, Hansen G, et al. A promoter interaction map for cardiovascular disease genetics. elife. 2018;7: pubmed publisher
Sharma A, Zhang Y, Buikema J, Serpooshan V, Chirikian O, Kosaric N, et al. Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation. Sci Rep. 2018;8:6618 pubmed publisher
Shafa M, Yang F, Fellner T, Rao M, Baghbaderani B. Human-Induced Pluripotent Stem Cells Manufactured Using a Current Good Manufacturing Practice-Compliant Process Differentiate Into Clinically Relevant Cells From Three Germ Layers. Front Med (Lausanne). 2018;5:69 pubmed publisher
Hoes M, Grote Beverborg N, Kijlstra J, Kuipers J, Swinkels D, Giepmans B, et al. Iron deficiency impairs contractility of human cardiomyocytes through decreased mitochondrial function. Eur J Heart Fail. 2018;20:910-919 pubmed publisher
Pfeiffer M, Quaranta R, Piccini I, Fell J, Rao J, Röpke A, et al. Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES. Nat Commun. 2018;9:440 pubmed publisher
Piccini I, Fehrmann E, Frank S, Müller F, Greber B, Seebohm G. Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast Kv7.1 Recycling. Front Physiol. 2017;8:705 pubmed publisher
Marczenke M, Piccini I, Mengarelli I, Fell J, Röpke A, Seebohm G, et al. Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells. Front Physiol. 2017;8:469 pubmed publisher
Bernatik O, Radaszkiewicz T, Behal M, Dave Z, Witte F, Mahl A, et al. A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation. Front Cell Dev Biol. 2017;5:47 pubmed publisher
Nigmatullina L, Norkin M, Dzama M, Messner B, Sayols S, Soshnikova N. Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development. EMBO J. 2017;36:869-885 pubmed publisher

product information

brand :

Tocris

master code :

5148

SKU :

5148/10

product name :

Wnt-C59

description :

Highly potent PORCN inhibitor

target :

PORCN Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

379.45

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/ -catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021 (Cat. No. 4423). Cell permeable and orally bioavailable.

catalog number base :

5148

product keywords :

Highly potent porcn inhibitors inhibits membrane-bound O-acyltransferase MBOAT Wnt signaling pathways WntC59 PORCN Cardiomyocyte Stem Cells ESCs and iPSC 5148,

extended description :

Highly potent PORCN inhibitor

chemical name text :

4-(2-Methyl-4-pyridinyl)-N-[4-(3-pyridinyl)phenyl]benzeneacetamide

formula :

C 25 H 21 N 3 O

formula text :

C25H21N3O

cas num :

1243243-89-1

2020 USD :

273

2021 USD :

284 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage