AZD 5582 dihydrochloride | Tocris Bioscience 5141 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZD 5582 dihydrochloride

catalog :

5141

quantity :

10 mg

price :

309 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Zinecker H, Ouaret D, Ebner D, Gaidt M, Taylor S, Aulicino A, et al. ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect. Oncotarget. 2017;8:106764-106777 pubmed publisher

product information

brand :

Tocris

master code :

5141

SKU :

5141/10

product name :

AZD 5582 dihydrochloride

description :

Dimeric Smac mimetic; potent IAP inhibitor

target :

Other ER Stress/UPR Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

97%

observed molecular weight :

1088.21

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.

catalog number base :

5141

product keywords :

AZD5582 dihydrochloride dimeric smac inhibitors potent x-linked cellular cIAP1 cIAP2 XIAP IAP inhibits apoptosis protein anticancer BIR3 domain 1258392-53-8 Inhibitor of Apoptosis (IAP) Other ER stress/UPR 5141,

extended description :

Dimeric Smac mimetic; potent IAP inhibitor

chemical name text :

3,3 -[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide

formula :

C 58 H 78 N 8 O 8 .2HCl

formula text :

C58H78N8O8.2HCl

cas num :

1883545-51-4

2020 USD :

297

2021 USD :

309 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage