AZD 5582 dihydrochloride | Tocris Bioscience 5141/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

AZD 5582 dihydrochloride

catalog :

5141/10

quantity :

10 mg

price :

390 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Hsieh E, Janssens D, Paddison P, Browne E, Henikoff S, OhAinle M, et al. A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency. PLoS Pathog. 2023;19:e1011101 pubmed publisher
Zhan Q, Jeon J, Li Y, Huang Y, Xiong J, Wang Q, et al. CAMK2/CaMKII activates MLKL in short-term starvation to facilitate autophagic flux. Autophagy. 2021;:1-19 pubmed publisher
Zinecker H, Ouaret D, Ebner D, Gaidt M, Taylor S, Aulicino A, et al. ICG-001 affects DRP1 activity and ER stress correlative with its anti-proliferative effect. Oncotarget. 2017;8:106764-106777 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5141

SKU :

5141/10

product name :

AZD 5582 dihydrochloride

Description :

Dimeric Smac mimetic; potent IAP inhibitor

target :

Other ER Stress/UPR Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

97%

observed molecular weight :

1088.21

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AZD 5582 dihydrochloride is a dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.

extended description :

Dimeric Smac mimetic; potent IAP inhibitor

chemical name text :

3,3 -[2,4-Hexadiyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide

formula :

C 58 H 78 N 8 O 8 .2HCl

formula text :

C58H78N8O8.2HCl

cas num :

1883545-51-4

USD :

390 USD

product details :

Dimeric Smac mimetic; potent IAP inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage