GSK 2830371 | Tocris Bioscience 5140 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 2830371

catalog :

5140

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5140

SKU :

5140/10

product name :

GSK 2830371

description :

Potent and selective allosteric inhibitor of Wip1 phosphatase

target :

Protein Ser/Thr Phosphatase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

461.02

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective allosteric inhibitor of Wip1 phosphatase (IC50 = 6 nM). Exhibits selectivity for Wip1 over 21 other phosphatases. Increases phosphorylation of Wip1 substrates, including p53, Chk2, H2AX and ATM. Attenuates tumor cell growth in a variety of lymphoid cell lines. Also inhibits lymphoma xenograft growth in vivo . Potentiates growth inhibitory effects of MDM2 inhibition in cancer cell lines in a p53-dependent manner. Orally bioavailable.

catalog number base :

5140

product keywords :

GSK2830371 potent selective allosteric inhibitors inhibits wip1 phosphatases antitumor orally bioavailable Protein Ser/Thr Phosphatases 5140,

extended description :

Potent and selective allosteric inhibitor of Wip1 phosphatase

chemical name text :

5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide

formula :

C 23 H 29 ClN 4 O 2 S

formula text :

C23H29ClN4O2S

cas num :

1404456-53-6

2020 USD :

222

2021 USD :

227 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage