GSK 2830371 | Tocris Bioscience 5140/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 2830371

catalog :

5140/10

quantity :

10 mg

price :

282 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Fox C, Parks G. Parainfluenza Virus Infection Sensitizes Cancer Cells to DNA-Damaging Agents: Implications for Oncolytic Virus Therapy. J Virol. 2018;92: pubmed publisher

image

image 1 :

Cat.No. 5140 - GSK 2830371 C23H29ClN4O2S CAS No. 1404456-53-6

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5140

SKU :

5140/10

product name :

GSK 2830371

Description :

Potent and selective allosteric inhibitor of Wip1 phosphatase

target :

Protein Ser/Thr Phosphatase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

461.02

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK 2830371 is a potent and selective allosteric inhibitor of Wip1 phosphatase (IC50 = 6 nM). Exhibits selectivity for Wip1 over 21 other phosphatases. Increases phosphorylation of Wip1 substrates, including p53, Chk2, H2AX and ATM. Attenuates tumor cell growth in a variety of lymphoid cell lines. Also inhibits lymphoma xenograft growth in vivo . Potentiates growth inhibitory effects of MDM2 inhibition in cancer cell lines in a p53-dependent manner. Orally bioavailable.

extended description :

Potent and selective allosteric inhibitor of Wip1 phosphatase

chemical name text :

5-[[(5-Chloro-2-methyl-3-pyridinyl)amino]methyl]-N-[(1S)-1-(cyclopentylmethyl)-2-(cycloprpylamino)-2-oxoethyl]-2-thiophenecarboxamide

formula :

C 23 H 29 ClN 4 O 2 S

formula text :

C23H29ClN4O2S

cas num :

1404456-53-6

USD :

282 USD

product details :

Potent and selective allosteric inhibitor of Wip1 phosphatase

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage