RSVA 405 | Tocris Bioscience 5138 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RSVA 405

catalog :

5138

quantity :

10 mg (also 50 mg)

price :

183 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Dai S, Dulcey A, Hu X, Wassif C, Porter F, Austin C, et al. Methyl-Î²-cyclodextrin restores impaired autophagy flux in Niemann-Pick C1-deficient cells through activation of AMPK. Autophagy. 2017;13:1435-1451 pubmed publisher

product information

brand :

Tocris

master code :

5138

SKU :

5138/10

product name :

RSVA 405

description :

AMPK activator; also STAT3 inhibitor

target :

AMPK Activators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

312.37

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

AMP-activated protein kinase (AMPK) activator (EC50 = 1 M); activates AMPK indirectly through a CaMKK -dependent mechanism. Also inhibits LPS-induced STAT3 phosphorylation (IC50 = 0.5 M). Induces autophagy and promotes A degradation in vitro . Also inhibits adipogenesis in vitro and reduces weight gain in diet-induced obese mice.

catalog number base :

5138

product keywords :

RSVA405 AMP-activated protein kinases activators inhibitors STAT3 indirect Ab Abeta A amyloid metabolism nf-kb nf- b cytokines inhibits AMPK STAT 5138,

extended description :

AMPK activator; also STAT3 inhibitor

chemical name text :

2-[[4-(Diethylamino)-2-hydroxyphenyl]methylene]hydrazide-4-pyridinecarboxylic acid

formula :

C 17 H 20 N 4 O 2

formula text :

C17H20N4O2

cas num :

140405-36-3

2020 USD :

183

2021 USD :

183 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage