MRT 67307 dihydrochloride | Tocris Bioscience 5134 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MRT 67307 dihydrochloride

catalog :

5134

quantity :

10 mg

price :

214 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris

master code :

5134

SKU :

5134/10

product name :

MRT 67307 dihydrochloride

description :

Salt inducible kinase (SIK) inhibitor

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

537.52

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Salt inducible kinase (SIK) inhibitor (IC50 values are 67, 250 and 430 nM for SIK2, SIK1 and SIK3 respectively). Also inhibits TBK1, MARK1-4, IKK and NUAK1 (IC50 values are 19, 27-52, 160 and 230 nM respectively). Has no effect on IKK or IKK . Induces IL-10 secretion and inhibits TNF- and IL-6 secretion in bacterial LPS-stimulated macrophages. Also enhances IL-1-induced activation of NF B-dependent gene transcription in mouse embryonic fibroblast (MEF) cells. Inhibits autophagy.

catalog number base :

5134

product keywords :

MRT67307 dihydrochloride salt inducible kinase SIK inhibitors inhibits TBK1 IKK IKKepsilon IKKe MARK NUAK Other Kinases Autophagy TANK binding kinase (TBK) 5134,

extended description :

Salt inducible kinase (SIK) inhibitor

chemical name text :

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride

formula :

C 26 H 36 N 6 O 2 .2HCl

formula text :

C26H36N6O2.2HCl

2020 USD :

205

2021 USD :

214 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage