MRT 67307 dihydrochloride | Tocris Bioscience 5134/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MRT 67307 dihydrochloride

catalog :

5134/10

quantity :

10 mg

price :

266 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
De Faveri F, Chvanov M, Voronina S, MOORE D, Pollock L, Haynes L, et al. LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells. Autophagy. 2020;16:1314-1331 pubmed publisher

image

image 1 :

Cat.No. 5134 - MRT 67307 dihydrochloride C26H36N6O2.2HCl

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5134

SKU :

5134/10

product name :

MRT 67307 dihydrochloride

Description :

Salt inducible kinase (SIK) inhibitor; also ULK1 and 2 inhibitor

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

537.52

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MRT 67307 dihydrochloride is a salt inducible kinase (SIK) inhibitor (IC50 values are 67, 250 and 430 nM for SIK2, SIK1 and SIK3 respectively) and a potent inhibitor of ULK1 and 2 (IC50 values of 45 and 38 nM, respectively). MRT 67307 dihydrochloride also inhibits TBK1, MARK1-4, IKK and NUAK1 (IC50 values are 19, 27-52, 160 and 230 nM respectively). Has no effect on IKK or IKK . Induces IL-10 secretion and inhibits TNF- and IL-6 secretion in bacterial LPS-stimulated macrophages. Also enhances IL-1-induced activation of NF B-dependent gene transcription in mouse embryonic fibroblast (MEF) cells. Inhibits autophagy.

extended description :

Salt inducible kinase (SIK) inhibitor; also ULK1 and 2 inhibitor

chemical name text :

N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride

formula :

C 26 H 36 N 6 O 2 .2HCl

formula text :

C26H36N6O2.2HCl

cas num :

1781882-89-0

USD :

266 USD

product details :

Salt inducible kinase (SIK) inhibitor; also ULK1 and 2 inhibitor

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage