UNC 0642 | Tocris Bioscience 5132 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

UNC 0642

catalog :

5132

quantity :

10 mg (also 50 mg)

price :

288 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Bellamy J, Szemes M, Melegh Z, Dallosso A, Kollareddy M, Catchpoole D, et al. Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma. Front Oncol. 2020;10:818 pubmed publisher

product information

brand :

Tocris

master code :

5132

SKU :

5132/10

product name :

UNC 0642

description :

Potent and selective G9a and GLP inhibitor

target :

G9a/GLP Inhibitor

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

546.7

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC50 2.5 nM). Exhibits 2,000-fold selectivity for G9a and GLP over PRC2-EZH2 and 20,000-fold selectivity over other methyltransferases. Reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC50 = 110 nM). Displays modest brain penetration in vivo .

catalog number base :

5132

product keywords :

UNC0642 potent selective G9a GLP histone lysine methyltransferase inhibits inhibitors HMTs HMTases epigenetics modifications H3K9 H3K9me2 sgc Lysine Methyltransferases G9a/GLP 5132,

extended description :

Potent and selective G9a and GLP inhibitor

chemical name text :

2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

formula :

C 29 H 44 F 2 N 6 O 2

formula text :

C29H44F2N6O2

cas num :

1481677-78-4

2020 USD :

276

2021 USD :

288 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage