UNC 0642 | Tocris Bioscience 5132/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

UNC 0642

catalog :

5132/10

quantity :

10 mg (also 50 mg)

price :

334 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Pribluda A, Daemen A, Lima A, Wang X, Hafner M, Poon C, et al. EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation. elife. 2022;11: pubmed publisher
Bellamy J, Szemes M, Melegh Z, Dallosso A, Kollareddy M, Catchpoole D, et al. Increased Efficacy of Histone Methyltransferase G9a Inhibitors Against MYCN-Amplified Neuroblastoma. Front Oncol. 2020;10:818 pubmed publisher
Yin C, Zhu B, Zhang T, Liu T, Chen S, Liu Y, et al. Pharmacological Targeting of STK19 Inhibits Oncogenic NRAS-Driven Melanomagenesis. Cell. 2019;176:1113-1127.e16 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5132

SKU :

5132/10

product name :

UNC 0642

Description :

Potent and selective G9a and GLP inhibitor

target :

G9a/GLP Inhibitor

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

546.7

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

UNC 0642 is a potent and selective G9a and GLP histone lysine methyltransferase inhibitor (IC50 2.5 nM) that exhibits 2,000-fold selectivity for G9a and GLP over PRC2-EZH2 and 20,000-fold selectivity over other methyltransferases. UNC 0642 reduces H3K9 dimethylation levels in MDA-MB-231 cells (IC50 = 110 nM), and displays modest brain penetration in vivo .

extended description :

Potent and selective G9a and GLP inhibitor

chemical name text :

2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine

formula :

C 29 H 44 F 2 N 6 O 2

formula text :

C29H44F2N6O2

cas num :

1481677-78-4

USD :

334 USD

product details :

Potent and selective G9a and GLP inhibitor

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage