NS 9283 | Tocris Bioscience 5112/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

NS 9283

catalog :

5112/10

quantity :

10 mg (also 50 mg)

price :

251 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Wang Z, Deba F, Mohamed T, Chiara D, Ramos K, Hamouda A. Unraveling amino acid residues critical for allosteric potentiation of (?4)3(?2)2-type nicotinic acetylcholine receptor responses. J Biol Chem. 2017;292:9988-10001 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5112

SKU :

5112/10

product name :

NS 9283

Description :

Positive allosteric modulator of 4 2 nAChRs

target :

Nicotinic (a4b2) Receptor Modulators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

248.24

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

NS 9283 is a positive allosteric modulator of 4 2 receptor; increases the potency of Ach-evoked currents ~60 fold without affecting the maximum efficacy (HEK293-h 4 2 cells). Reduces the rate of recovery from desensitization and slows the rate of deactivation. Displays a synergistic effect on the Emax when given with NS206 at 3 :2 receptors.

extended description :

Positive allosteric modulator of 4 2 nAChRs

chemical name text :

3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile

formula :

C 14 H 8 N 4 O

formula text :

C14H8N4O

cas num :

913830-15-6

USD :

251 USD

product details :

Positive allosteric modulator of 4 2 nAChRs

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage