GSK 1838705 | Tocris Bioscience 5111/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 1838705

catalog :

5111/10

quantity :

10 mg (also 50 mg)

price :

343 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Anderson K, Hamilton W, Roske F, Azad A, Knudsen T, Canham M, et al. Insulin fine-tunes self-renewal pathways governing naive pluripotency and extra-embryonic endoderm. Nat Cell Biol. 2017;19:1164-1177 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5111

SKU :

5111/10

product name :

GSK 1838705

Description :

Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)

target :

Insulin and Insulin-like Receptor Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

532.57

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK 1838705 is a potent insulin receptor (IR) and insulin-like growth factor-1 receptor (IGF1R) inhibitor (IC50 values are 1.6 and 2 nM, respectively). Also inhibits anaplastic lymphoma kinase (ALK) (IC50 = 0.5 nM). Displays 800-fold selectivity for IR, IGFR1 and ALK over a panel of 44 kinases including JNK. Blocks proliferation of cancer cell lines in vitro , and causes complete regression of ALK-dependent tumors in vivo . Orally bioavailable.

extended description :

Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)

chemical name text :

2-[[2-[[1-[(Dimethylamino)ethanoyl]-5-(methyloxy)-2,3-dihydro-1H-indol-6-yl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino]-6-fluoro-N-methylbenzamide

formula :

C 27 H 29 FN 8 O 3

formula text :

C27H29FN8O3

cas num :

1116235-97-2

USD :

343 USD

product details :

Potent IR and IGF1R inhibitor; also inhibits anaplastic lymphoma kinase (ALK)

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage