GSK 2606414 | Tocris Bioscience 5107 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 2606414

catalog :

5107

quantity :

10 mg (also 50 mg)

price :

281 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Samluk L, Urbanska M, Kisielewska K, Mohanraj K, Kim M, Machnicka K, et al. Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress. Mol Biol Cell. 2019;:mbcE18100628 pubmed publisher
Mahameed M, Wilhelm T, Darawshi O, Obiedat A, Tommy W, Chintha C, et al. The unfolded protein response modulators GSK2606414 and KIRA6 are potent KIT inhibitors. Cell Death Dis. 2019;10:300 pubmed publisher
Park S, Lim Y, Lee D, Elvira R, Lee J, Lee M, et al. Modulation of Protein Synthesis by eIF2α Phosphorylation Protects Cell from Heat Stress-Mediated Apoptosis. Cells. 2018;7: pubmed publisher
Leznicki P, Natarajan J, Bader G, Spevak W, Schlattl A, Abdul Rehman S, et al. Expansion of DUB functionality generated by alternative isoforms - USP35, a case study. J Cell Sci. 2018;131: pubmed publisher
Topf U, Suppanz I, Samluk L, Wrobel L, Böser A, Sakowska P, et al. Quantitative proteomics identifies redox switches for global translation modulation by mitochondrially produced reactive oxygen species. Nat Commun. 2018;9:324 pubmed publisher

product information

brand :

Tocris

master code :

5107

SKU :

5107/10

product name :

GSK 2606414

description :

Potent and selective PERK inhibitor; orally bioavailable

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

451.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective protein kinase R-like ER kinase (PERK) inhibitor (IC50 = 0.4 nM). Exhibits 1000-fold selectivity for PERK over HR1 and PKR. Inhibits thapsigargin-induced PERK phosphorylation in lung carcinoma A549 cells. Attenuates subcutaneous pancreatic human tumor xenograft growth in mice. Orally bioavailable.

catalog number base :

5107

product keywords :

GSK2606414 potent selective protein kinase R-like ER kinase PERK orally bioavailable antitumor ER-stress PERK 5107,

extended description :

Potent and selective PERK inhibitor; orally bioavailable

chemical name text :

1-[5-(4-Amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-2,3-dihydro-1H-indol-1-yl]-2-[3-(trifluoromethyl)phenyl]ethanone

formula :

C 24 H 20 F 3 N 5 O

formula text :

C24H20F3N5O

cas num :

1337531-36-8

2020 USD :

270

2021 USD :

281 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage