GSK 2193874 | Tocris Bioscience 5106 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 2193874

catalog :

5106

quantity :

25 mg

price :

467 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Neubert P, Homann A, Wendelborn D, Bär A, Krampert L, Trum M, et al. NCX1 represents an ionic Na+ sensing mechanism in macrophages. PLoS Biol. 2020;18:e3000722 pubmed publisher
Xu S, Liu B, Yin M, Koroleva M, Mastrangelo M, Ture S, et al. A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis. Oncotarget. 2016;7:37622-37635 pubmed publisher
Chen Y, Fang Q, Wang Z, Zhang J, Macleod A, Hall R, et al. Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch. J Biol Chem. 2016;291:10252-62 pubmed publisher

product information

brand :

Tocris

master code :

5106

SKU :

5106/25

product name :

GSK 2193874

description :

Potent and selective TRPV4 antagonist; orally active

target :

TRPV Antagonists

category :

Small Molecules

unit size :

25 mg

purity :

98%

observed molecular weight :

691.62

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective TRPV4 antagonist (IC50 values are 2 and 40 nM for rat and human receptors, respectively); inhibits Ca2+ influx through TRPV4 channels. Prevents and reverses pulmonary edema after myocardial infarction in vivo models. Selective over a panel of ~200 human receptors, channels and enzymes. Orally active.

catalog number base :

5106

product keywords :

GSK2193874 potent selectiveTRPV4 inhibitors antagonists orally active transient receptors potential vanilloids channels myocardial infarction pulmonary oedema edema inhibits TRPV 5106,

extended description :

Potent and selective TRPV4 antagonist; orally active

chemical name text :

3-([1,4 -Bipiperidin]-1 -ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

formula :

C 37 H 38 BrF 3 N 4 O

formula text :

C37H38BrF3N4O

cas num :

1336960-13-4

2020 USD :

457

2021 USD :

467 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage