GSK 2193874 | Tocris Bioscience 5106/5 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GSK 2193874

catalog :

5106/5

quantity :

5 mg (also 25 mg)

price :

154 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Bai H, Si L, Jiang A, Belgur C, Zhai Y, Plebani R, et al. Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip. Nat Commun. 2022;13:1928 pubmed publisher
Hernández Morales M, Han V, Kramer R, Liu C. Evaluating methods and protocols of ferritin-based magnetogenetics. iScience. 2021;24:103094 pubmed publisher
Daneva Z, Ottolini M, Chen Y, Klimentova E, Kuppusamy M, Shah S, et al. Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice. elife. 2021;10: pubmed publisher
Wong N, Mohan J, Kopecky B, Guo S, Du L, Leid J, et al. Resident cardiac macrophages mediate adaptive myocardial remodeling. Immunity. 2021;54:2072-2088.e7 pubmed publisher
Patel P, Chen Y, Kasetti R, Maddineni P, Mayhew W, Millar J, et al. Impaired TRPV4-eNOS signaling in trabecular meshwork elevates intraocular pressure in glaucoma. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Neubert P, Homann A, Wendelborn D, Bär A, Krampert L, Trum M, et al. NCX1 represents an ionic Na+ sensing mechanism in macrophages. PLoS Biol. 2020;18:e3000722 pubmed publisher
Hernández Morales M, Shang T, Chen J, Han V, Liu C. Lipid Oxidation Induced by RF Waves and Mediated by Ferritin Iron Causes Activation of Ferritin-Tagged Ion Channels. Cell Rep. 2020;30:3250-3260.e7 pubmed publisher
Xu S, Liu B, Yin M, Koroleva M, Mastrangelo M, Ture S, et al. A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis. Oncotarget. 2016;7:37622-37635 pubmed publisher
Chen Y, Fang Q, Wang Z, Zhang J, Macleod A, Hall R, et al. Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch. J Biol Chem. 2016;291:10252-62 pubmed publisher

image

image 1 :

Cat.No. 5106 - GSK 2193874 C37H38BrF3N4O CAS No. 1336960-13-4

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5106

SKU :

5106/5

product name :

GSK 2193874

Description :

Potent and selective TRPV4 antagonist; orally active

target :

TRPV Antagonists

category :

Small Molecules

unit size :

5 mg (also 25 mg)

purity :

98%

observed molecular weight :

691.62

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

GSK 2193874 is a potent and selective TRPV4 antagonist (IC50 values are 2 and 40 nM for rat and human receptors, respectively); inhibits Ca2+ influx through TRPV4 channels. Prevents and reverses pulmonary edema after myocardial infarction in vivo models. Selective over a panel of ~200 human receptors, channels and enzymes. Orally active.

extended description :

Potent and selective TRPV4 antagonist; orally active

chemical name text :

3-([1,4 -Bipiperidin]-1 -ylmethyl)-7-bromo-N-(1-phenylcyclopropyl)-2-[3-(trifluoromethyl)phenyl]-4-quinolinecarboxamide

formula :

C 37 H 38 BrF 3 N 4 O

formula text :

C37H38BrF3N4O

cas num :

1336960-13-4

USD :

154 USD

product details :

Potent and selective TRPV4 antagonist; orally active

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage