A12B4C3 | Tocris Bioscience 5097 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

A12B4C3

catalog :

5097

quantity :

10 mg (also 50 mg)

price :

268 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Freschauf G, Mani R, Mereniuk T, Fanta M, Virgen C, Dianov G, et al. Mechanism of action of an imidopiperidine inhibitor of human polynucleotide kinase/phosphatase. J Biol Chem. 2010;285:2351-60 pubmed publisher
Freschauf G, Karimi Busheri F, Ulaczyk Lesanko A, Mereniuk T, Ahrens A, Koshy J, et al. Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase. Cancer Res. 2009;69:7739-46 pubmed publisher

product information

brand :

Tocris

master code :

5097

SKU :

5097/10

product name :

A12B4C3

description :

Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor

target :

Other Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

534.65

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor (IC50 = 60 nM). Displays no effect on calcineurin, protein PP-1 or APTX. Interrupts DNA repair and enhances radiosensitivity of human A549 lung carcinoma and MDA-MB-231 cells.

catalog number base :

5097

product keywords :

Potent selective polynucleotide kinases phosphatases PKNP inhibitors inhibits DNA repair Other Kinases 5097,

extended description :

Potent and selective polynucleotide kinase/phosphatase (PNKP) inhibitor

chemical name text :

4a,7a-Dihydro-2-(1-hydroxyundecyl)-1-[(4-nitrophenyl)amino]-6-phenyl-1H-pyrrolo[3,4-b]pyridine-5,7(2H,6H)-dione

formula :

C 30 H 38 N 4 O 5

formula text :

C30H38N4O5

cas num :

1005129-80-5

2020 USD :

257

2021 USD :

268 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage