TC-S 7004 | Tocris Bioscience 5088 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TC-S 7004

catalog :

5088

quantity :

10 mg (also 50 mg)

price :

219 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Blake D, Vaseva A, Hodge R, Kline M, Gilbert T, Tyagi V, et al. Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. Sci Signal. 2019;12: pubmed publisher

product information

brand :

Tocris

master code :

5088

SKU :

5088/10

product name :

TC-S 7004

description :

Potent and selective DYRK1A/B inhibitor

target :

DYRK Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

498.32

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective DYRK1A/B inhibitor (IC50 values are 22 and 68 nM respectively). Selective for DYRK1A/B over a panel of other kinases. Reduces accumulation of quiescent Panc1 pancreatic cancer cells in G0 under serum free conditions. Also induces DNA damage and apoptosis in quiescent Panc1 cells.

catalog number base :

5088

product keywords :

TC-S7004 Mirk DYRK1B DYRK1A potent inhibitors inhibits DYRK 5088,

extended description :

Potent and selective DYRK1A/B inhibitor

chemical name text :

N-[2-Chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxopyrido[2,3-d]pyrimidine-6-carboxamide

formula :

C 23 H 17 Cl 2 N 5 O 4

formula text :

C23H17Cl2N5O4

cas num :

1386979-55-0

2020 USD :

212

2021 USD :

219 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage