TC-S 7004 | Tocris Bioscience 5088/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

TC-S 7004

catalog :

5088/10

quantity :

10 mg (also 50 mg)

price :

273 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Blake D, Vaseva A, Hodge R, Kline M, Gilbert T, Tyagi V, et al. Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer. Sci Signal. 2019;12: pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5088

SKU :

5088/10

product name :

TC-S 7004

Description :

Potent and selective DYRK1A/B inhibitor

target :

DYRK Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

498.32

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

TC-S 7004 is a potent and selective DYRK1A/B inhibitor (IC50 values are 22 and 68 nM respectively). Selective for DYRK1A/B over a panel of other kinases. Reduces accumulation of quiescent Panc1 pancreatic cancer cells in G0 under serum free conditions. Also induces DNA damage and apoptosis in quiescent Panc1 cells.

extended description :

Potent and selective DYRK1A/B inhibitor

chemical name text :

N-[2-Chloro-5-[[[(3-chlorophenyl)methyl]amino]carbonyl]phenyl]-7,8-dihydro-2-methoxy-7-oxopyrido[2,3-d]pyrimidine-6-carboxamide

formula :

C 23 H 17 Cl 2 N 5 O 4

formula text :

C23H17Cl2N5O4

cas num :

1386979-55-0

USD :

273 USD

product details :

Potent and selective DYRK1A/B inhibitor

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage