J 147 | Tocris Bioscience 5081/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

J 147

catalog :

5081/10

quantity :

10 mg (also 50 mg)

price :

227 USD

more info or order :

Tocris Bioscience product webpage

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

5081

SKU :

5081/10

product name :

J 147

Description :

Neuroprotective and neurotrophic compound; reduces A 40 and A 42 levels

target :

Amyloid beta Peptides

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

350.33

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

J 147 is a potent neuroprotective and neurotrophic compound. Protects against neurotoxicity in cortical neurons in vitro (EC50 = 25 - 200 nM). Reduces soluble A 40 and A 42 levels and increases BDNF levels in the hippocampus in vivo . Enhances memory in wild type rats. Prevents memory deficits and rescues cognitive deficits in young and aged transgenic Alzheimer s disease mice, respectively. Orally active.

extended description :

Neuroprotective and neurotrophic compound; reduces A 40 and A 42 levels

chemical name text :

2,2,2-Trifluoroacetic acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide

formula :

C 18 H 17 F 3 N 2 O 2

formula text :

C18H17F3N2O2

cas num :

1146963-51-0

USD :

227 USD

product details :

Neuroprotective and neurotrophic compound; reduces A 40 and A 42 levels

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage